An investigation into the prognostic significance of necrosis and hypoxia in high grade and invasive bladder cancer.

Journal article

PURPOSE: We investigated hypoxia and necrosis in high grade and invasive bladder cancer, and related this to prognosis. MATERIALS AND METHODS: We performed a retrospective observational study of 98 primary cystectomy specimens scored for necrosis, and the hypoxia associated markers carbonic anhydrase IX, hypoxia-inducible factor 1 alpha and 2 alpha, and Bcl2/adenovirus EIB 19 kDa interacting protein 3. Tumor tissue array was used with cores taken from representative and perinecrotic tumor re...

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Authors: Ord, J; Agrawal, S; Thamboo, T; Roberts, I; Campo, L

• Publication status: Published
• Journal: Journal of urology
• Volume: 178
• Issue: 2
• Pages: 677-682
• Publication date: 2007-08-01
• DOI: 10.1016/j.juro.2007.03.112
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: Neoplasm Staging; Aged; Proto-Oncogene Proteins; Antigens, Neoplasm; Female; Cell Hypoxia; Neovascularization, Pathologic; Tissue Array Analysis; Retrospective Studies; Necrosis; Basic Helix-Loop-Helix Transcription Factors; Urinary Bladder; Membrane Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Lymph Nodes; Prognosis; Male; Humans; Carbonic Anhydrases; Carcinoma, Transitional Cell; Neoplasm Invasiveness; Urinary Bladder Neoplasms