Journal article

Enantiopure bicyclic piperidinones: stereoselectivity in lactam enolate alkylations.

Abstract:: The synthesis and alkylation of [4.3.0]-bicyclic lactams, derived from 6-oxopipecolic acid, have been investigated. Alkylation can proceed with predominantly exo-diastereoselectivity, but the efficiency of this process depends on the substitution at the hemiaminal ether system. These products can be readily deprotected to give substituted hydroxymethyl lactams in good yield.

Publication status:: Published

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APA Style

Brewster, A., Broady, S., Davies, C., Heightman, T., Hermitage, S. A., Hughes, M., Moloney, M., & Woods, G. (2004). Enantiopure bicyclic piperidinones: stereoselectivity in lactam enolate alkylations. Organic and Biomolecular Chemistry, 2(7), 1031–1043.

MLA Style

Brewster, A, et al. “Enantiopure Bicyclic Piperidinones: Stereoselectivity in Lactam Enolate Alkylations.” Organic and Biomolecular Chemistry, vol. 2, no. 7, 2004, pp. 1031–43.

Chicago Style

Brewster, A, S Broady, C Davies, et al. 2004. “Enantiopure Bicyclic Piperidinones: Stereoselectivity in Lactam Enolate Alkylations.” Organic and Biomolecular Chemistry 2 (7): 1031–43.
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Publisher copy:: 10.1039/b316037h

Authors

+ Brewster, A More by this author

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+ Broady, S More by this author

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+ Davies, C More by this author

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+ Heightman, T More by this author

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+ Hermitage, SA More by this author

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Journal:: Organic and biomolecular chemistry More from this journal
Volume:: 2
Issue:: 7
Pages:: 1031-1043
Publication date:: 2004-04-01
DOI:: 10.1039/b316037h
EISSN:: 1477-0539
ISSN:: 1477-0520

Language:: English
Pubs id:: pubs:32660
UUID:: uuid:0e4dc58a-f1e9-45a0-9f94-03f73fe9e1a1
Local pid:: pubs:32660
Source identifiers:: 32660
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_0e4dc58af1e945a09f9403f73fe9e1a1

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Copyright date:: 2004

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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