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Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.

Abstract:

BACKGROUND: Lowering of LDL cholesterol with standard statin regimens reduces the risk of occlusive vascular events in a wide range of individuals. We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin therapy. METHODS: We undertook meta-analyses of individual participant data from randomised trials involving at least 1000 participants and at least 2 years' treatment duration of more versus less intensive statin regimens (five trials; 39 612 indi...

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Publication status:
Published

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Authors


Baigent, C More by this author
Blackwell, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Holland, LE More by this author
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Journal:
Lancet
Volume:
376
Issue:
9753
Pages:
1670-1681
Publication date:
2010-11-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:0e2f5d8d-35f6-40c2-9b9b-a515d8b530e3
Source identifiers:
97243
Local pid:
pubs:97243

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