Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.

Journal article

BACKGROUND: Lowering of LDL cholesterol with standard statin regimens reduces the risk of occlusive vascular events in a wide range of individuals. We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin therapy. METHODS: We undertook meta-analyses of individual participant data from randomised trials involving at least 1000 participants and at least 2 years' treatment duration of more versus less intensive statin regimens (five trials; 39 612 indi...

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Authors: Baigent, C; Blackwell, L; Emberson, J; Holland, L; Reith, C

• Publication status: Published
• Journal: Lancet
• Volume: 376
• Issue: 9753
• Pages: 1670-1681
• Publication date: 2010-11-01
• DOI: 10.1016/s0140-6736(10)61350-5
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Stroke; Cholesterol, LDL; Myocardial Infarction; Cholesterol Treatment Trialists’ (CTT) Collaboration; Randomized Controlled Trials as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Coronary Disease