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Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: A reciprocal risk factor for depression and insulin resistance?

Abstract:

Depression and diabetes are serious diseases with an increasing global prevalence. Intriguingly, recent meta-analyses have highlighted an asymmetrical relationship between the two conditions as depressed patients were found to display a higher risk of developing type 2 diabetes than those individuals suffering from diabetes are to become depressed. Based on recent findings, we favor a hypothesis where by decreased peripheral serotonin (5-HT) transporter (5-HTT) function is a reciprocal risk f...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbr.2014.04.049

Authors


Pomytkin, IA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Steinbusch, HW More by this author
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Journal:
Behavioural brain research
Volume:
276C
Pages:
111-117
Publication date:
2015-01-05
DOI:
EISSN:
1872-7549
ISSN:
0166-4328
URN:
uuid:0e2df8a1-74c3-41de-87a2-9151ce591ea3
Source identifiers:
464928
Local pid:
pubs:464928

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