Some p53-binding proteins that can function as arbiters of life and death.

Journal article

Four sets of p53-binding proteins are discussed in this review. These are the E2F family, the ASPP family, Y-box-binding protein YB1, and the prolyl isomerase Pin1. Each appears to play a role in the decision by p53 to induce an arrest of cell proliferation or apoptosis and they may also be independent markers of cancer. Their activities appear to be linked with the cell cycle and they may also interact with each other. In this review, the properties of each protein class are discussed as well as how they affect p53 functions. A model is proposed as to how their activities might be coordinated.

Authors: Braithwaite, A; Del Sal, G; Lu, X

• Publication status: Published
• Journal: Cell death and differentiation
• Volume: 13
• Issue: 6
• Pages: 984-993
• Publication date: 2006-06-01
• DOI: 10.1038/sj.cdd.4401924
• EISSN: 1476-5403
• ISSN: 1350-9047
• Language: English
• Keywords: Peptidylprolyl Isomerase; Apoptosis; Cell Cycle Proteins; Cell Transformation, Neoplastic; Intracellular Signaling Peptides and Proteins; Nuclear Proteins; Apoptosis Regulatory Proteins; Cell Proliferation; Animals; Carrier Proteins; Humans; Neoplasms; Transcription, Genetic; E2F Transcription Factors; Adaptor Proteins, Signal Transducing; Tumor Suppressor Protein p53; DNA-Binding Proteins