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Biomarkers in amyotrophic lateral sclerosis.

Abstract:

Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive disorder. After half a century of trials, only one drug with modest disease-modifying potency--riluzole--has been developed. The diagnosis of this disorder is still clinical and there is a pronounced delay between the onset of symptoms and diagnosis, possibly beyond the therapeutic window. Bedside quantification of the involvement of the corticospinal tract and extramotor areas is inadequate and functional...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
The Lancet. Neurology
Volume:
8
Issue:
1
Pages:
94-109
Publication date:
2009-01-05
DOI:
EISSN:
1474-4465
ISSN:
1474-4422
URN:
uuid:0dfeac80-b080-4e9f-85eb-1a7e449acb2a
Source identifiers:
245042
Local pid:
pubs:245042

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