Peripheral blood mononuclear cells from patients with chronic renal failure release factors which suppress erythropoietin secretion in vitro.

Journal article

Decreased production of erythropoietin (Epo) as a result of reduced renal mass is considered the main factor underlying the anaemia that is invariably associated with chronic renal failure (CRF). Other mechanisms such as accumulation of inhibitors of Epo also contribute. In this study we show that supernatant from peripheral blood mononuclear cells (PBMC) cultured from patients with CRF inhibits Epo release by Hep G2 cells in vitro. Ten patients (5 male) with CRF (mean age 42 years, range 25-...

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Authors: Cassidy, M; De Jager, C; Ebrahim, O; Camachio, P; Robson, S

• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
• Volume: 9
• Issue: 7
• Pages: 775-779
• Publication date: 1994-01-01
• EISSN: 1460-2385
• ISSN: 0931-0509
• Language: English
• Keywords: Radioimmunoassay; Erythropoietin; Antibodies; Kidney Failure, Chronic; Monocytes; Interleukin-1; Tumor Cells, Cultured; Female; Middle Aged; Renal Dialysis; Humans; Adult; Cells, Cultured; Tumor Necrosis Factor-alpha; Lipopolysaccharides; Male