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Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects.

Abstract:

Preincubation of rat pancreatic islets with AICA riboside (0.1 to 1.0mM) caused a concentration-related stimulation of both 45Ca net uptake and insulin release evoked by 8.3 mM D-glucose, but failed to affect the conversion of D-[5-3H]glucose to 3HOH, the generation of 14CO2 and 14C-labelled amino acids or acidic metabolites from D-[U-14C]glucose, and the islet content in ATP, ADP or AMP. The secretory response to AICA riboside was not suppressed in islets preincubated with methotrexate. AICA...

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Authors


Malaisse, WJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Diabetes research (Edinburgh, Scotland)
Volume:
25
Issue:
1
Pages:
25-37
Publication date:
1994
ISSN:
0265-5985
URN:
uuid:0df0ba32-878e-4d74-87bd-ffa8f80c5386
Source identifiers:
4399
Local pid:
pubs:4399

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