- Abstract:
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BACKGROUND: Subjects with non-O ABO blood group alleles have increased risk of pancreatic cancer. Glycosyltransferase activity is greater for the A(1) versus A(2) variant, whereas O01 and O02 variants are nonfunctioning. We hypothesized: 1) A(1) allele would confer greater risk than A(2) allele, 2) protective effect of the O allele would be equivalent for O01 and O02 variants, 3) secretor phenotype would modify the association with risk. METHODS: We determined ABO variants and secretor phenot...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1158/1055-9965.epi-10-0751
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- Journal:
- Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Volume:
- 19
- Issue:
- 12
- Pages:
- 3140-3149
- Publication date:
- 2010-12-05
- DOI:
- EISSN:
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1538-7755
- ISSN:
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1055-9965
- URN:
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uuid:0df04230-a86b-45be-96de-6e93e83b7062
- Source identifiers:
-
110374
- Local pid:
- pubs:110374
- Copyright date:
- 2010
Journal article
Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium.
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