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Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies.

Abstract:

There is a major need in target validation and therapeutic applications for molecules that can interfere with protein function inside cells. Intracellular antibodies (intrabodies) can bind to specific targets in cells but isolation of intrabodies is currently difficult. Intrabodies are normally single chain Fv fragments comprising variable domains of the immunoglobulin heavy (VH) and light chains (VL). We now demonstrate that single VH domains have excellent intracellular properties of solubi...

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Authors


Lobato, MN More by this author
Rabbitts, TH More by this author
Journal:
Journal of molecular biology
Volume:
331
Issue:
5
Pages:
1109-1120
Publication date:
2003-08-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:0debfd57-b29b-4fb4-9fe6-f961c355c4e8
Source identifiers:
324281
Local pid:
pubs:324281

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