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Palladium-catalyzed allylic fluorination.

Abstract:
Mild and rapid: The title reaction is presented and its applicability to 18F radiolabeling is demonstrated (see scheme; TBAF=tetra-n- butylammonium fluoride, THF=tetrahydrofuran, dba=dibenzylideneacetone). The use of p-nitrobenzoate as the leaving group is significant to the success of this catalytic organometallic fluorination process. A range of allylic fluorides were synthesized by this method. Copyright © 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.201007307

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Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
50
Issue:
11
Pages:
2613-2617
Publication date:
2011-03-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851


Language:
English
Keywords:
Pubs id:
pubs:120221
UUID:
uuid:0deaca31-b997-4ff5-94da-eb8dfc5f9665
Local pid:
pubs:120221
Source identifiers:
120221
Deposit date:
2012-12-19
ARK identifier:

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