Journal article
Structural basis of promiscuous substrate transport by Organic Cation Transporter 1
- Abstract:
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Pyrrolizidine alkaloids (PAs) are secondary plant metabolites, which can occur as contaminants in predominantly plant-based foods. Only 1,2-unsatured PAs are bioactivated by cytochrome P450 (CYP450) enzymes, especially CYP3A4, into DNA reactive metabolites, which are known to be genotoxic and hepatoxic in vivo. The PA toxicity is strongly influenced by the chemical structure as demonstrated by several in vitro studies. However, quantitative genotoxicity data are needed, particularly in primar...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 4.0MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-023-42086-9
Authors
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 14
- Issue:
- 1
- Pages:
- 6374-6374
- Publication date:
- 2023-10-11
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Language:
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English
- Keywords:
- Pubs id:
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2359135
- Local pid:
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pubs:2359135
- Source identifiers:
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W4387541028
- Deposit date:
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2026-01-15
- ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.
Terms of use
- Copyright date:
- 2023
- Licence:
- CC Attribution (CC BY)
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