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The role of the HNF4alpha enhancer in type 2 diabetes.

Abstract:

The genetic causes of type 2 diabetes are not well understood. The disease has been linked to chromosome 20q12-q13.1 a region which harbors the transcription factor HNF4alpha. Mutations in the coding region of HNF4alpha cause maturity onset diabetes of the young, an autosomal dominant form of diabetes, but do not account for the linkage to this region. An enhancer element has recently been characterized 6 kb 5' of the HNF4alpha P1 promoter containing binding sites for the transcription factor...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
Molecular genetics and metabolism
Volume:
76
Issue:
2
Pages:
148-151
Publication date:
2002-06-05
DOI:
EISSN:
1096-7206
ISSN:
1096-7192
URN:
uuid:0de29c3c-16b2-4c43-86b0-d91441a5d668
Source identifiers:
6668
Local pid:
pubs:6668

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