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Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.

Abstract:

Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) -4 and ADAMTS-5 are considered to be the main enzymes responsible for aggrecan breakdown, making them attractive drugs targets. Here we show that calcium pentosan polysulfate (CaPPS), a chemically sulfated xylanopyranose from beechwood, is a multifaceted exosite inhibitor of the aggrecanases and protects cartilage against aggrecan degrada...

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Publication status:
Published

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Publisher copy:
10.1096/fj.08-112680

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
22
Issue:
10
Pages:
3515-3524
Publication date:
2008-10-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:0dda8039-9e70-4af1-84ee-d361ac25def8
Source identifiers:
227193
Local pid:
pubs:227193

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