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A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

Abstract:

The recurrent translocation t(5;11)(q35;p15.5) associated with a 5q deletion, del(5q), has been reported in childhood acute myeloid leukemia (AML). We report the cloning of the translocation breakpoints in de novo childhood AML harboring a cryptic t(5;11)(q35;p15.5). Fluorescence in situ hybridization (FISH) analysis demonstrated that the nucleoporin gene (NUP98) at 11p15.5 was disrupted by this translocation. By using 3'--rapid amplification of complementary DNA ends (3'-RACE) polymerase cha...

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Publication status:
Published

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Publisher copy:
10.1182/blood.v98.4.1264

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Journal:
Blood
Volume:
98
Issue:
4
Pages:
1264-1267
Publication date:
2001-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:0dd8f9d5-d684-4096-8d60-4a5da7e2699f
Source identifiers:
246204
Local pid:
pubs:246204

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