- Abstract:
-
OBJECTIVE: The FRZB gene codes for secreted frizzled-related protein 3 (sFRP3), a soluble antagonist of wnt signalling that is required for maintaining cartilage integrity. Two common single nucleotide polymorphisms (SNPs) that code for the substitution of conserved arginine residues have previously been identified in FRZB and found to be associated with osteoarthritis (OA). Functional studies revealed that the arginine substitutions lead to a loss-of-function of sFRP3 activity. We set out to...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.joca.2006.06.016
-
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- Journal:
- Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
- Volume:
- 15
- Issue:
- 1
- Pages:
- 90-92
- Publication date:
- 2007-01-05
- DOI:
- EISSN:
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1522-9653
- ISSN:
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1063-4584
- URN:
-
uuid:0dd080bf-f40b-44d7-82a9-24038a4d56ec
- Source identifiers:
-
108484
- Local pid:
- pubs:108484
- Copyright date:
- 2007
Journal article
Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility.
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