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Journal article

Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility.

Abstract:

OBJECTIVE: The FRZB gene codes for secreted frizzled-related protein 3 (sFRP3), a soluble antagonist of wnt signalling that is required for maintaining cartilage integrity. Two common single nucleotide polymorphisms (SNPs) that code for the substitution of conserved arginine residues have previously been identified in FRZB and found to be associated with osteoarthritis (OA). Functional studies revealed that the arginine substitutions lead to a loss-of-function of sFRP3 activity. We set out to...

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Publication status:
Published

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Publisher copy:
10.1016/j.joca.2006.06.016

Authors


Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Volume:
15
Issue:
1
Pages:
90-92
Publication date:
2007-01-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:0dd080bf-f40b-44d7-82a9-24038a4d56ec
Source identifiers:
108484
Local pid:
pubs:108484

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