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The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells.

Abstract:

Hypoxia-inducible factor-1 (HIF-1), a DNA-binding complex implicated in the regulation of gene expression by oxygen, has been shown to consist of a heterodimer of two basic helix-loop-helix Per-AHR-ARNT-Sim (PAS) proteins, HIF-1alpha, and HIF-1beta. One partner, HIF-1beta, had been recognized previously as the aryl hydrocarbon receptor nuclear translocator (ARNT), an essential component of the xenobiotic response. In the present work, ARNT-deficient mutant cells, originally derived from the m...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.271.25.15117

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
271
Issue:
25
Pages:
15117-15123
Publication date:
1996-06-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:0dcfa415-7f31-4ff2-b5c8-cf6b98e24ea1
Source identifiers:
22886
Local pid:
pubs:22886

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