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Three-dimensional hydrogel structures as optical sensor arrays, for the detection of specific DNA sequences

Abstract:

The fabrication and characterization of surface-attached PEG-diacrylate hydrogel structures and their application as sensing platforms for the detection of specific target sequences are reported. Hydrogel structures were formed by a photopolymerization process, using substrate-bound Eosin Y molecules for the production of free radicals. We have demonstrated that this fabrication process allows for control over hydrogel growth down to the micrometer scale. Confocal imaging revealed relatively ...

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Publisher copy:
10.1016/j.ab.2011.10.026

Authors


Kivlehan, F More by this author
Paolucci, M More by this author
Brennan, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Analytical Biochemistry
Volume:
421
Issue:
1
Pages:
1-8
Publication date:
2012-02-01
DOI:
EISSN:
1096-0309
ISSN:
0003-2697
URN:
uuid:0d97e96f-96c5-418c-9e8d-ed4d58827cd0
Source identifiers:
313327
Local pid:
pubs:313327

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