Translational inhibition of cyclin B1 and appearance of cyclin D1 very early in the differentiation of mouse trophoblast giant cells.

Journal article

Investigation of the basis of uncoupling of replication of the genome from mitosis in the mouse trophoblast has so far been neglected despite its significance for understanding both placental development and cell cycle control. In order to obtain clues about the molecular basis of the switch from proliferation to endoreduplication, we have investigated changes in the expression of cyclins and cyclin-dependent kinases in diploid versus giant trophoblast cells. Interestingly, while cyclin B1 tr...

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Authors: Palazón, L; Davies, T; Gardner, R

• Publication status: Published
• Journal: Molecular human reproduction
• Volume: 4
• Issue: 11
• Pages: 1013-1020
• Publication date: 1998-11-01
• DOI: 10.1093/molehr/4.11.1013
• EISSN: 1460-2407
• ISSN: 1360-9947
• Language: English
• Keywords: Trophoblasts; Cell Cycle; Pregnancy; Gene Expression Regulation, Developmental; Mice; Cell Differentiation; Animals; Female; Cyclin D1; Polyploidy; Giant Cells; Cyclin B