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Translational inhibition of cyclin B1 and appearance of cyclin D1 very early in the differentiation of mouse trophoblast giant cells.

Abstract:

Investigation of the basis of uncoupling of replication of the genome from mitosis in the mouse trophoblast has so far been neglected despite its significance for understanding both placental development and cell cycle control. In order to obtain clues about the molecular basis of the switch from proliferation to endoreduplication, we have investigated changes in the expression of cyclins and cyclin-dependent kinases in diploid versus giant trophoblast cells. Interestingly, while cyclin B1 tr...

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Publication status:
Published

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Publisher copy:
10.1093/molehr/4.11.1013

Authors


Palazón, LS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Gardner, RL More by this author
Journal:
Molecular human reproduction
Volume:
4
Issue:
11
Pages:
1013-1020
Publication date:
1998-11-05
DOI:
EISSN:
1460-2407
ISSN:
1360-9947
URN:
uuid:0d93710e-770c-42a7-b893-3a7d774ea2c1
Source identifiers:
55436
Local pid:
pubs:55436

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