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Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.

Abstract:

Inhibitor of growth protein-2 (ING2) is a nuclear adaptor protein that can regulate p53 and histone acetylation in response to cellular stress and contains a PHD (plant homeodomain) finger that can interact with phosphatidylinositol-5-phosphate (PtdIns5P). However, whether or how nuclear PtdIns5P levels are regulated in response to cellular stress or whether ING2 can sense these changes has not been demonstrated. We show that UV irradiation increases nuclear PtdIns5P levels via inhibition of ...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
23
Issue:
5
Pages:
685-695
Publication date:
2006-09-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:0d8b1c6c-1f66-4cbb-ae42-da249364516d
Source identifiers:
384631
Local pid:
pubs:384631

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