Journal article
The interleukin 22 pathway interacts with mutant KRAS to promote poor prognosis in colon cancer.
- Abstract:
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Purpose: The cytokine interleukin 22 (IL-22) promotes tumor progression in murine models of colorectal cancer (CRC). However, the clinical significance of IL-22 in human CRC remains unclear. We sought to determine whether the IL-22 pathway is associated with prognosis in human CRC, and to identify mechanisms by which IL-22 can influence disease progression. Experimental Design: Transcriptomic data from stage II/III colon cancers in independent discovery (GSE39582 population-based cohort, N=56...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 5.0MB, Terms of use)
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(Preview, Supplementary materials, Accepted manuscript, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1158/1078-0432.ccr-19-1086
Authors
Bibliographic Details
- Publisher:
- American Association for Cancer Research
- Journal:
- Clinical Cancer Research More from this journal
- Volume:
- 26
- Issue:
- 16
- Pages:
- 4313-4325
- Place of publication:
- United States
- Publication date:
- 2020-05-19
- Acceptance date:
- 2020-05-14
- DOI:
- EISSN:
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1557-3265
- ISSN:
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1078-0432
- Pmid:
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32430479
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1106055
- Local pid:
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pubs:1106055
- Deposit date:
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2020-06-12
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2020, American Association for Cancer Research.
- Notes:
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This is the accepted manuscript version of the article. The final version is available from American Association for Cancer Research at https://doi.org/10.1158/1078-0432.CCR-19-1086
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