CTL priming by CD8(+) and CD8(-) dendritic cells in vivo.

Journal article

Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been suggested to induce tolerance. Here we show that both subsets activate CD8(+) T cells in vitro and induce protective anti-viral CTL responses in vivo. Thus, vaccine strategies using peptide-pulsed DC do not have to take into account DC subsets for priming.

Authors: Ruedl, C; Bachmann, M

• Publication status: Published
• Publisher: Wiley
• Journal: European journal of immunology
• Volume: 29
• Issue: 11
• Pages: 3762-3767
• Publication date: 1999-11-01
• DOI: 10.1002/(sici)1521-4141(199911)29:11<3762::aid-immu3762>3.3.co;2-6
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Mice; Immunophenotyping; T-Lymphocytes, Cytotoxic; Antigens, CD8; Spleen; Mice, Inbred C57BL; Lymph Nodes; Animals; Dendritic Cells