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CTL priming by CD8(+) and CD8(-) dendritic cells in vivo.

Abstract:

Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been suggested to induce tolerance. Here we show that both subsets activate CD8(+) T cells in vitro and induce protective anti-viral CTL responses in vivo. ...

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Publication status:
Published

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Authors


Bachmann, MF More by this author
Publisher:
Wiley-VCH Verlag
Journal:
European journal of immunology
Volume:
29
Issue:
11
Pages:
3762-3767
Publication date:
1999-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:0d81b430-48f0-4a3e-8af2-2a3a75958206
Source identifiers:
469224
Local pid:
pubs:469224

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