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Early events in kidney donation: progression of endothelial activation, oxidative stress and tubular injury after brain death.

Abstract:

Cerebral injury leading to brain death (BD) causes major physiologic derangements in potential organ donors, which may result in vascular-endothelial activation and affect posttransplant graft function. We investigated the kinetic of pro-coagulatory and pro-inflammatory endothelial activation and the subsequent oxidative stress and renal tubular injury, early after BD declaration. BD was induced by slowly inflating a balloon-catheter inserted in the extradural space over a period of 30 min. R...

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Publication status:
Published

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Authors


Morariu, AM More by this author
Schuurs, TA More by this author
Leuvenink, HG More by this author
van Oeveren, W More by this author
Rakhorst, G More by this author
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Journal:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume:
8
Issue:
5
Pages:
933-941
Publication date:
2008-05-05
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:0d7f850d-65f0-42fd-8225-dfb4fa48f871
Source identifiers:
190842
Local pid:
pubs:190842

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