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The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction.

Abstract:

We examined the regulation of calcium signalling in atrial cardiomyocytes during excitation-contraction coupling, and how changes in the distribution of calcium impacts on contractility. Under control conditions, calcium transients originated in subsarcolemmal locations and showed local regeneration through activation of calcium-induced calcium release from ryanodine receptors. Despite functional ryanodine receptors being expressed at regular (approximately 2 microm) intervals throughout atri...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.01559

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Journal of cell science
Volume:
117
Issue:
Pt 26
Pages:
6327-6337
Publication date:
2004-12-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:0d792f12-cff5-4f66-a720-64674436bbd5
Source identifiers:
52008
Local pid:
pubs:52008

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