Journal article
The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2
- Abstract:
-
Background Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and differentiation and currently no membrane proteins have been linked to ERK2 scaffolding. Methods and results Here, we identify the human Na+/H+ exchanger 1 (hNHE1) as a membrane scaffold protein for ERK2 and show direct hNHE1-ERK1/2 interaction in cellular contexts. Using nuclear magnetic resonance (NMR) spectroscopy and immu...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 2.6MB, Terms of use)
-
- Publisher copy:
- 10.1186/s12915-016-0252-7
Authors
Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- BMC Biology More from this journal
- Volume:
- 14
- Article number:
- 31
- Publication date:
- 2016-04-15
- Acceptance date:
- 2016-03-29
- DOI:
- ISSN:
-
1741-7007
- Pmid:
-
27083547
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:617602
- UUID:
-
uuid:0d71af1f-8ffc-4a6b-b689-074c84f65562
- Local pid:
-
pubs:617602
- Source identifiers:
-
617602
- Deposit date:
-
2017-08-17
Terms of use
- Copyright holder:
- Hendus-Altenburger et al
- Copyright date:
- 2016
- Notes:
- Copyright © Hendus-Altenburger et al. 2016.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record