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The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

Abstract:

Background Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and differentiation and currently no membrane proteins have been linked to ERK2 scaffolding. Methods and results Here, we identify the human Na+/H+ exchanger 1 (hNHE1) as a membrane scaffold protein for ERK2 and show direct hNHE1-ERK1/2 interaction in cellular contexts. Using nuclear magnetic resonance (NMR) spectroscopy and immu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1186/s12915-016-0252-7

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Publisher:
BioMed Central Publisher's website
Journal:
BMC Biology Journal website
Volume:
14
Pages:
Article: 31
Publication date:
2016-04-15
Acceptance date:
2016-03-29
DOI:
ISSN:
1741-7007
Pubs id:
pubs:617602
URN:
uri:0d71af1f-8ffc-4a6b-b689-074c84f65562
UUID:
uuid:0d71af1f-8ffc-4a6b-b689-074c84f65562
Local pid:
pubs:617602

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