Nitric-oxide-mediated regulation of cardiac contractility and stretch responses.

Journal article

In the heart, nitric oxide (NO) is constitutively produced by the vascular and endocardial endothelium, the cardiomyocytes and the autonomic nerves. Whereas stimulation of NO release from the vascular endothelium has consistently been shown to quicken the onset of left ventricular (LV) relaxation and cause a small reduction in peak contraction, the role of myocardial NO production in regulating cardiac function appears to be more complex and controversial. Some studies have shown that non-iso...

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Authors: Casadei, B; Sears, C

• Publication status: Published
• Journal: Progress in biophysics and molecular biology
• Volume: 82
• Issue: 1-3
• Pages: 67-80
• Publication date: 2003-01-01
• DOI: 10.1016/s0079-6107(03)00006-3
• EISSN: 1873-1732
• ISSN: 0079-6107
• Language: English
• Keywords: Arginine; Animals; Protein Isoforms; Signal Transduction; Heart Ventricles; Mice; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Time Factors; Myocardial Contraction; Dose-Response Relationship, Drug; Rats