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Journal article

Regional and global changes in TCRalphabeta T cell repertoires in the gut are dependent upon the complexity of the enteric microflora.

Abstract:

The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing on intra-epithelial lymphocyte compartments. Using GF, conventional and monocolonised (gnotobiotic) chickens and chicken TCRbeta-repertoire analysis techniques, we determined the influence of microbial status on global and regional enteric TC...

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Publication status:
Published

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Publisher copy:
10.1016/j.dci.2009.11.009

Authors


Mwangi, WN More by this author
Humphrey, T More by this author
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Journal:
Developmental and comparative immunology
Volume:
34
Issue:
4
Pages:
406-417
Publication date:
2010-04-05
DOI:
EISSN:
1879-0089
ISSN:
0145-305X
URN:
uuid:0d637a68-ae1e-48d0-b960-0a651f6ad767
Source identifiers:
132252
Local pid:
pubs:132252

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