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An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

Abstract:

Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively. Recently, we demonstrated that ferroportin is also found in cardiomyocytes, and that its cardiac-specific deletion leads to fatal cardiac iron overload. Hepcidin is also expressed in cardiomyocytes, where its function remains unknown. To define the function of cardiomyocyte hep...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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10.7554/eLife.19804

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
5
Issue:
e19804
Publication date:
2016-11-29
Acceptance date:
2016-11-24
DOI:
ISSN:
2050-084X
Pubs id:
pubs:662609
URN:
uri:0d6367ad-d800-4109-af4c-e603c0b7824a
UUID:
uuid:0d6367ad-d800-4109-af4c-e603c0b7824a
Local pid:
pubs:662609
Language:
English
Keywords:

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