Journal article
Plasma biomarkers of HIV-related systemic inflammation and immune activation in sub-Saharan Africa before and during suppressive antiretroviral therapy
- Abstract:
- We evaluated immune biomarker profiles in HIV-infected adults (n=398) from 5 African countries. Although all biomarkers decreased after ART initiation, CXCL10, LBP, CRP, sCD163 and sCD14 were significantly higher during ART than in an HIV-negative reference group (n=90), indicating persistent monocyte/macrophage activation, inflammation and microbial translocation. Before ART initiation, high HIV viral load was associated with elevated CXCL10 and tuberculosis coinfection was associated with elevated sCD14. High pre-ART levels of each biomarker strongly predicted residual immune activation during ART. CCL2, LBP, CRP, IL-6 were differentially expressed between countries. Further research is needed on the clinical implications of residual immune dysregulation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 244.2KB, Terms of use)
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- Publisher copy:
- 10.1093/infdis/jiz252
Authors
- Publisher:
- Oxford University Press
- Journal:
- Journal of infectious diseases More from this journal
- Volume:
- 220
- Issue:
- 6
- Pages:
- 1029-1033
- Publication date:
- 2019-05-14
- Acceptance date:
- 2019-04-15
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Pmid:
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31086991
- Language:
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English
- Keywords:
- Pubs id:
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pubs:999614
- UUID:
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uuid:0d60a4fc-7dbf-47ef-9495-a715130a1ae8
- Local pid:
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pubs:999614
- Source identifiers:
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999614
- Deposit date:
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2019-05-21
- ARK identifier:
Terms of use
- Copyright holder:
- Kroeze et al
- Copyright date:
- 2019
- Notes:
- © The Authors. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected]
- Licence:
- CC Attribution (CC BY)
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