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The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen

Abstract:

Introduction: The purpose of the present study was to investigate the relationship of expression of hypoxia inducible factor (HIF)-1α-modifying enzymes prolyl hydroxylase (PHD)1, PHD2 and PHD3 to response of tumours and survival in breast cancer patients enrolled in a phase II trial of neoadjuvant anthracycline and tamoxifen therapy.Methods: The expression of PHD1, PHD2 and PHD3 together with HIF-1α and the HIF-inducible genes vascular endothelial cell growth factor (VEGF) and carbonic anhydr...

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Publisher copy:
10.1186/bcr2825

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Journal:
Breast Cancer Research
Volume:
13
Issue:
1
Publication date:
2011-02-03
DOI:
EISSN:
1465-542X
ISSN:
1465-5411
URN:
uuid:0d5bd5e9-b6df-4dfb-a537-3b696277a769
Source identifiers:
329837
Local pid:
pubs:329837
Language:
English

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