Journal article
The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen
- Abstract:
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Introduction: The purpose of the present study was to investigate the relationship of expression of hypoxia inducible factor (HIF)-1α-modifying enzymes prolyl hydroxylase (PHD)1, PHD2 and PHD3 to response of tumours and survival in breast cancer patients enrolled in a phase II trial of neoadjuvant anthracycline and tamoxifen therapy.Methods: The expression of PHD1, PHD2 and PHD3 together with HIF-1α and the HIF-inducible genes vascular endothelial cell growth factor (VEGF) and carbonic anhydr...
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- Publisher copy:
- 10.1186/bcr2825
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Authors
Bibliographic Details
- Journal:
- Breast Cancer Research
- Volume:
- 13
- Issue:
- 1
- Publication date:
- 2011-02-03
- DOI:
- EISSN:
-
1465-542X
- ISSN:
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1465-5411
- Source identifiers:
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329837
Item Description
- Language:
- English
- Pubs id:
-
pubs:329837
- UUID:
-
uuid:0d5bd5e9-b6df-4dfb-a537-3b696277a769
- Local pid:
- pubs:329837
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2011
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