Journal article

Synthesis of the enantiomers of 6-epicastanospermine and 1,6-diepicastanospermine from D- and L-gulonolactone.

Abstract:: The synthesis of the enantiomers of 6-epicastanospermine and of 1,6-diepicastanospermine from the enantiomeric gulonolactones is reported and the structure of the former is established as (1S,6R,7R,8R,8aR)-1,6,7,8-tetrahydroxyoctahydroindolizine. The inhibitory activities of the diastereomers against the amyloglucosidase-catalysed hydrolysis of p-nitrophenyl alpha-D-glucopyranoside were investigated, and the effects of 6-epicastanospermine and of 1,6-diepicastanospermine on 14 human liver glycosidases are reported.

Publication status:: Published

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APA Style

Fleet, G., Ramsden, N., Nash, R., Fellows, L., Jacob, G., Molyneux, R., di Bello, I., & Winchester, B. (1990). Synthesis of the enantiomers of 6-epicastanospermine and 1,6-diepicastanospermine from D- and L-gulonolactone. Carbohydrate Research, 205(C), 269–282.

MLA Style

Fleet, G, et al. “Synthesis of the Enantiomers of 6-Epicastanospermine and 1,6-Diepicastanospermine from D- and L-Gulonolactone.” Carbohydrate Research, vol. 205, no. C, 1990, pp. 269–82.

Chicago Style

Fleet, G, N Ramsden, R Nash, et al. 1990. “Synthesis of the Enantiomers of 6-Epicastanospermine and 1,6-Diepicastanospermine from D- and L-Gulonolactone.” Carbohydrate Research 205 (C): 269–82.
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Publisher copy:: 10.1016/0008-6215(90)80146-t

Authors

+ Fleet, G More by this author

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+ Ramsden, N More by this author

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+ Nash, R More by this author

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+ Fellows, L More by this author

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+ Jacob, G More by this author

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Journal:: Carbohydrate research More from this journal
Volume:: 205
Issue:: C
Pages:: 269-282
Publication date:: 1990-09-01
DOI:: 10.1016/0008-6215(90)80146-t
EISSN:: 1873-426X
ISSN:: 0008-6215

Language:: English
Keywords:: Molecular Structure

Glycoside Hydrolases

Humans

Stereoisomerism

Liver

Magnetic Resonance Spectroscopy

Indolizines

Sugar Acids
Pubs id:: pubs:43469
UUID:: uuid:0d5b431a-6897-47f4-9de6-4d5e542f6694
Local pid:: pubs:43469
Source identifiers:: 43469
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_0d5b431a689747f49de64d5e542f6694

Terms of use

Copyright date:: 1990

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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