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New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold.

Abstract:
In this Letter we describe the design, synthesis, screening, and optimization of a new family of ADAMTS-5 inhibitors. These inhibitors display an original 1,2,4-triazole-3-thiol scaffold as a putative zinc binding-group. In vitro results are rationalized by in silico docking of the compounds in ADAMTS-5's crystal structure.
Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2010.08.108

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Bioorganic and medicinal chemistry letters More from this journal
Volume:
20
Issue:
21
Pages:
6213-6216
Publication date:
2010-11-01
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:226408
UUID:
uuid:0d5255fb-8091-4102-8af6-b223966d97d4
Local pid:
pubs:226408
Source identifiers:
226408
Deposit date:
2012-12-19

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