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Modls: Post-translational modification localization scoring with automatic specificity expansion

Abstract:

Probability-based localization scoring of fragment mass-spectrum phosphorylation site identifications has become common practice to confirm search engine modification assignments, and indicate the degree of certainty with which they are defined. Localization of modifications other than phosphorylation is also required but is less commonly supported by current tools. These other modifications, such as hydroxylation, may have broad aminoacid specificity, and can be misassigned when the correct ...

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Publisher copy:
10.4172/jpb.1000251

Authors


Trudgian, DC More by this author
Singleton, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Kessler, BM More by this author
Journal:
Journal of Proteomics and Bioinformatics
Volume:
5
Issue:
12
Pages:
285-291
Publication date:
2012
DOI:
EISSN:
0974-276X
URN:
uuid:0d4b46bd-20f0-4081-a03d-8e5f467cb031
Source identifiers:
379425
Local pid:
pubs:379425

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