Multi-site intradermal and multi-site subcutaneous rabies vaccination: improved economical regimens.

Journal article

Neutralising antibody responses to six post-exposure regimens of human diploid cell strain rabies vaccine with or without human rabies immune globulin (HRIG) were studied in 98 patients. The total amount of vaccine used was 22-34% of that required by conventional regimens. Vaccine was given at multiple sites intradermally or subcutaneously with or without adjuvant. Antibody was detectable within 7 days of the first dose in all subjects only in the groups given 0.1 ml intradermally at 8 sites. From day 14 onwards all groups showed an excellent antibody response; there was little difference between the various regimens. Suppression of the response to 8-site intradermal vaccination by a large dose of HRIG could be prevented by giving the second dose of vaccine on day 7 rather than day 14.

Authors: Warrell, M; Suntharasamai, P; Nicholson, K; Warrell, D; Chanthavanich, P

• Publication status: Published
• Journal: Lancet
• Volume: 1
• Issue: 8382
• Pages: 874-876
• Publication date: 1984-04-01
• DOI: 10.1016/s0140-6736(84)91340-0
• EISSN: 1474-547X
• ISSN: 0140-6736
• Language: English
• Keywords: Antibodies, Viral; Male; Adolescent; Humans; Female; Costs and Cost Analysis; Adjuvants, Immunologic; Rabies; Vaccination; Rabies Vaccines; Middle Aged; Adult; Injections, Subcutaneous; Injections, Intradermal; Time Factors; Child; Immunization, Passive; Aged