VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma

Journal article

Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively characterized, frequently involving inactivation of the von Hippel–Lindau (VHL) tumor suppressor. Roles for noncoding cis-regulatory aberrations in ccRCC tumorigenesis, however, remain unclear. Analyzing 10 primary tumor/normal pairs and 9 cell lines across 79 chromatin profiles, we observed pervasive enhancer malfunction in ccRCC, with cognate enhancer-target genes associated with tissue-specific asp...

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Authors: Yao, X; Tan, J; Lim, K; Koh, J; Ooi, W

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Association for Cancer Research Publisher's website
• Journal: Cancer Discovery Journal website
• Volume: 7
• Issue: 11
• Pages: 1284-1305
• Publication date: 2017-09-11
• Acceptance date: 2017-08-25
• DOI: 10.1158/2159-8290.cd-17-0375
• EISSN: 2159-8290
• ISSN: 2159-8274
• Pmid: 28893800
• Language: English
• Keywords: casic helix-loop-helix transcription factors; cell line, tumor; transcription factors; p300-CBP transcription factors; chromatin; regulatory sequences, nucleic acid; mutation; carcinogenesis; gene expression regulation, neoplastic; enhancer elements, genetic; promoter regions, genetic; oncogenes; DNA-binding proteins; von Hippel-Lindau tumor suppressor protein; carcinoma, renal cell