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Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

Abstract:

BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function.

METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included 16 traits of left ventricular (LV) structure, and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/JCI84840

Authors


Schillert, A More by this author
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Grant:
Center for Translational Vascular Biology
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
127
Issue:
5
Pages:
1798-1812
Publication date:
2017-04-10
Acceptance date:
2017-02-16
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pubs id:
pubs:697221
URN:
uri:0d31dcb4-feee-4fcc-88a0-ecb4927a8e7a
UUID:
uuid:0d31dcb4-feee-4fcc-88a0-ecb4927a8e7a
Local pid:
pubs:697221
Keywords:

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