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Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Abstract:

Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may carry a sufficient cost to viral replicative capacity to facilitate subsequent immune control of a now attenuated virus. In order to examine how limitations can be imposed on viral escape, the epitope TSTLQEQIGW (TW10 [Gag residues 240 to 249]), presented by two HLA alleles associated with effective c...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
Journal of virology
Volume:
80
Issue:
7
Pages:
3617-3623
Publication date:
2006-04-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:0d25bffc-aff7-43fc-adaa-78f949383f05
Source identifiers:
13051
Local pid:
pubs:13051

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