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Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

Abstract:: A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy- α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells. © 2012 Elsevier Ltd. All rights reserved.

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APA Style

Jervis, P., Moulis, M., Jukes, J., Ghadbane, H., Cox, L., Cerundolo, V., & Besra, G. (2012). Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues. Carbohydrate Research, 356, 152–162.

MLA Style

Jervis, P., et al. “Towards Multivalent CD1d Ligands: Synthesis and Biological Activity of Homodimeric α-Galactosyl Ceramide Analogues.” Carbohydrate Research, vol. 356, 2012, pp. 152–62.

Chicago Style

Jervis, P, M Moulis, J Jukes, H Ghadbane, L Cox, V Cerundolo, and G Besra. 2012. “Towards Multivalent CD1d Ligands: Synthesis and Biological Activity of Homodimeric α-Galactosyl Ceramide Analogues.” Carbohydrate Research 356: 152–62.
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Publisher copy:: 10.1016/j.carres.2012.02.034

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+ Moulis, M More by this author

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Bibliographic Details

Journal:: Carbohydrate Research
Volume:: 356
Pages:: 152-162
Publication date:: 2012-07-15
DOI:: 10.1016/j.carres.2012.02.034
EISSN:: 1873-426X
ISSN:: 0008-6215

Item Description

Language:: English
Keywords:: CD1d

Dimer

Multivalency

α-GalCer

Click chemistry

iNKT cells
Pubs id:: pubs:341425
UUID:: uuid:0d1fe74f-1345-4818-80c2-cfb40ffb7820
Local pid:: pubs:341425
Source identifiers:: 341425
Deposit date:: 2012-12-19

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Copyright date:: 2012

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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