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Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal.

Abstract:

Carbon dioxide is a potent cerebral vasodilator. We have identified a significant source of low-frequency variation in blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) signal at 3 T arising from spontaneous fluctuations in arterial carbon dioxide level in volunteers at rest. Fluctuations in the partial pressure of end-tidal carbon dioxide (Pet(CO(2))) of +/-1.1 mm Hg in the frequency range 0-0.05 Hz were observed in a cohort of nine volunteers. Correlating with these fluct...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
NeuroImage More from this journal
Volume:
21
Issue:
4
Pages:
1652-1664
Publication date:
2004-04-01
DOI:
EISSN:
1095-9572
ISSN:
1053-8119

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