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Journal article

Use of lithium (alpha-methylbenzyl)allylamide for a formal asymmetric synthesis of thienamycin

Abstract:: The highly stereoselective conjugate addition of lithium (αR)-(α-methylbenzyl)allylamide 3 to (E)-tert-butyl penta-2,4-dienoate 4, followed by a stereoselective aldol reaction with acetaldehyde, are the key steps in the synthesis of the known β-lactam intermediate, (3S,4R)-3-E(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-vinylazetidin-2-one 2, for elaboration to thienamycin and its derivatives.

Publication status:: Published

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APA Style

Davies, S., & Fenwick, D. R. (1997). Use of lithium (alpha-methylbenzyl)allylamide for a formal asymmetric synthesis of thienamycin. CHEMICAL COMMUNICATIONS, 6, 565–566.

MLA Style

Davies, S., and D. R. Fenwick. “Use of Lithium (Alpha-Methylbenzyl)Allylamide for a Formal Asymmetric Synthesis of Thienamycin.” CHEMICAL COMMUNICATIONS, no. 6, 1997, pp. 565–66.

Chicago Style

Davies, S, and DR Fenwick. 1997. “Use of Lithium (Alpha-Methylbenzyl)Allylamide for a Formal Asymmetric Synthesis of Thienamycin.” CHEMICAL COMMUNICATIONS, no. 6: 565–66.
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Publisher copy:: 10.1039/a700216e

Authors

+ Davies, S More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Sub department:

Organic Chemistry

Role:

Author

+ Fenwick, DR More by this author

Role:

Author

Bibliographic Details

Journal:: CHEMICAL COMMUNICATIONS
Issue:: 6
Pages:: 565-566
Publication date:: 1997-03-21
DOI:: 10.1039/a700216e
EISSN:: 1364-548X
ISSN:: 1359-7345

Item Description

Pubs id:: pubs:110834
UUID:: uuid:0d09c818-00ff-4252-b190-a71395895f2a
Local pid:: pubs:110834
Source identifiers:: 110834
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 1997

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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