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Journal article

Light-driven post-translational installation of reactive protein side chains

Abstract:

Post-translational modifications (PTMs) greatly expand the structures and functions of proteins in nature. Although synthetic protein functionalization strategies allow mimicry of PTMs, as well as formation of unnatural protein variants with diverse potential functions, including drug carrying, tracking, imaging and partner crosslinking, the range of functional groups that can be introduced remains limited. Here we describe the visible-light-driven installation of side chains at dehydroalanin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-020-2733-7

Authors


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Role:
Author
ORCID:
0000-0001-6182-0879
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-0748-0284
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
585
Issue:
7826
Pages:
530-537
Place of publication:
England
Publication date:
2020-09-23
Acceptance date:
2020-07-15
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
32968259
Language:
English
Keywords:
Pubs id:
1133408
Local pid:
pubs:1133408
Deposit date:
2020-10-06

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