Medical therapy of Cushing's disease: where are we now?

Journal article

The goals of ideal medical therapy for Cushing's disease should be to target the aetiology of the disorder, and thus surgery is the current 'gold standard' treatment. However, no effective drug that directly and effectively targets the adrenocorticotropin-secreting pituitary adenoma has been found to date, and treatments to control the hypercortisolaemic state by adrenal-based therapy are frequently used. Inhibitors of adrenal steroidogenesis, adrenolytic agents, compounds with neuromodulator...

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Authors: Alexandraki, K; Grossman, AB

• Publication status: Published
• Journal: Frontiers of hormone research
• Volume: 38
• Pages: 165-173
• Publication date: 2010-01-01
• DOI: 10.1159/000318507
• EISSN: 1662-3762
• ISSN: 0301-3073
• Language: English
• Keywords: Ketoconazole; Humans; Somatostatin; Mifepristone; Dopamine Agonists; Pituitary ACTH Hypersecretion; Hydrocortisone; Mitotane; Metyrapone