- Abstract:
-
C16orf35 is a conserved and widely expressed gene lying adjacent to the human α-globin cluster in all vertebrate species. In-depth sequence analysis shows that C16orf35 (now called NPRL3) is an orthologue of the yeast gene Npr3 (nitrogen permease regulator 3) and, furthermore, is a paralogue of its protein partner Npr2. The yeast Npr2/3 dimeric protein complex senses amino acid starvation and appropriately adjusts cell metabolism via the TOR pathway. Here we have analysed a mouse model in whi...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s00335-012-9398-y
-
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- Journal:
- Mammalian genome : official journal of the International Mammalian Genome Society
- Volume:
- 23
- Issue:
- 7-8
- Pages:
- 404-415
- Publication date:
- 2012-08-05
- DOI:
- EISSN:
-
1432-1777
- ISSN:
-
0938-8990
- URN:
-
uuid:0d07256e-2ef6-4516-9643-6a1deef2dc4f
- Source identifiers:
-
325587
- Local pid:
- pubs:325587
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Nprl3 is required for normal development of the cardiovascular system.
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