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Journal article

Nprl3 is required for normal development of the cardiovascular system.

Abstract:

C16orf35 is a conserved and widely expressed gene lying adjacent to the human α-globin cluster in all vertebrate species. In-depth sequence analysis shows that C16orf35 (now called NPRL3) is an orthologue of the yeast gene Npr3 (nitrogen permease regulator 3) and, furthermore, is a paralogue of its protein partner Npr2. The yeast Npr2/3 dimeric protein complex senses amino acid starvation and appropriately adjusts cell metabolism via the TOR pathway. Here we have analysed a mouse model in whi...

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Publication status:
Published

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Publisher copy:
10.1007/s00335-012-9398-y

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Mammalian genome : official journal of the International Mammalian Genome Society
Volume:
23
Issue:
7-8
Pages:
404-415
Publication date:
2012-08-05
DOI:
EISSN:
1432-1777
ISSN:
0938-8990
URN:
uuid:0d07256e-2ef6-4516-9643-6a1deef2dc4f
Source identifiers:
325587
Local pid:
pubs:325587

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