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Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes.

Abstract:

Cytotoxic T cells (CTL) recognize short peptide epitopes presented by class I glycoproteins encoded by the major histocompatibility complex (MHC). It is not yet known whether peptides containing posttranslationally modified amino acids can also be recognized by CTL. To address this issue, we have studied the immunogenicity and recognition of a glycopeptide carrying an O-linked N-acetylglucosamine (GlcNAc) monosaccharide-substituted serine residue. This posttranslational modification is cataly...

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Publication status:
Published

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Publisher copy:
10.1084/jem.180.2.739

Authors


Haurum, JS More by this author
Arsequell, G More by this author
Lellouch, AC More by this author
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Journal:
The Journal of experimental medicine
Volume:
180
Issue:
2
Pages:
739-744
Publication date:
1994-08-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:0d03a882-be04-41d4-bf6c-4f44c070a60f
Source identifiers:
35775
Local pid:
pubs:35775

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