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Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival.

Abstract:

BACKGROUND: Reverse transcription-PCR (RT-PCR) assays have been used for analysis of circulating tumor cells (CTCs), but their clinical value has yet to be established. We assessed men with localized prostate cancer or castration-refractory prostate cancer (CRPC) for CTCs via real-time RT-PCR assays for KLK3 [kallikrein-related peptidase 3; i.e., prostate-specific antigen (PSA)] and KLK2 mRNAs. We also assessed the association of CTCs with disease characteristics and survival. METHODS: KLK3, ...

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Journal:
Clinical chemistry More from this journal
Volume:
55
Issue:
4
Pages:
765-773
Publication date:
2009-04-01
DOI:
EISSN:
1530-8561
ISSN:
0009-9147
Language:
English
Keywords:
Pubs id:
pubs:365916
UUID:
uuid:0d03616e-d1c9-4635-8b23-5beb9b29372d
Local pid:
pubs:365916
Source identifiers:
365916
Deposit date:
2013-11-16

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