The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group.

Tubridy, N; Behan, PO; Capildeo, R; Chaudhuri, A; Forbes, R; Hawkins, CP; Hughes, RA; Palace, J; Sharrack, B; Swingler, R; Young, C; Moseley, IF; MacManus, DG; Donoghue, S; Miller, DH

Abstract:

OBJECTIVE: To determine the effect of humanized monoclonal antibody against alpha4 integrin (reactive with alpha4beta1 integrin or very-late antigen-4) on MRI lesion activity in MS. METHODS: A randomized, double-blind, placebo-controlled trial in 72 patients with active relapsing-remitting and secondary progressive MS was performed. Each patient received two IV infusions of anti-alpha4 integrin antibody (natalizumab; Antegren) or placebo 4 weeks apart and was followed up for 24 weeks with ser...

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APA Style

Tubridy, N., Behan, P. O., Capildeo, R., Chaudhuri, A., Forbes, R., Hawkins, C. P., Hughes, R. A., Palace, J., Sharrack, B., Swingler, R., Young, C., Moseley, I. F., MacManus, D. G., Donoghue, S., & Miller, D. H. (1999). The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group. Neurology, 53(3), 466–472.

MLA Style

Tubridy, N., et al. “The Effect of Anti-alpha4 Integrin Antibody on Brain Lesion Activity in MS. The UK Antegren Study Group.” Neurology, vol. 53, no. 3, Neurology, 1999, pp. 466–72.

Chicago Style

Tubridy, N, PO Behan, R Capildeo, A Chaudhuri, R Forbes, CP Hawkins, RA Hughes, et al. 1999. “The Effect of Anti-alpha4 Integrin Antibody on Brain Lesion Activity in MS. The UK Antegren Study Group.” Neurology 53 (3): 466–72.
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Authors

Tubridy, N More by this author

Behan, PO More by this author

Capildeo, R More by this author

Chaudhuri, A More by this author

Forbes, R More by this author

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Bibliographic Details

Journal:: Neurology
Volume:: 53
Issue:: 3
Pages:: 466-472
Publication date:: 1999-08-11
ISSN:: 0028-3878
URN:: uuid:0d01e46c-0c63-437a-8ac2-2a5d4db1a21f
Source identifiers:: 387044
Local pid:: pubs:387044

Item Description

Language:: English
Keywords:: Male

Antibodies, Monoclonal

Prognosis

Middle Aged

Humans

Integrin alpha4

Brain

Adult

Female

Magnetic Resonance Imaging

Double-Blind Method

Antigens, CD

Multiple Sclerosis

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