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A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform.

Abstract:

Mathematical modeling of Ca(2+) dynamics in the heart has the potential to provide an integrated understanding of Ca(2+)-handling mechanisms. However, many previous published models used heterogeneous experimental data sources from a variety of animals and temperatures to characterize model parameters and motivate model equations. This methodology limits the direct comparison of these models with any particular experimental data set. To directly address this issue, in this study, we present a...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00219.2010

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
299
Issue:
4
Pages:
H1045-H1063
Publication date:
2010-10-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:0cfdc367-b311-4825-beed-46fd6a67883c
Source identifiers:
65913
Local pid:
pubs:65913

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