- Abstract:
-
BACKGROUND: Efavirenz is a second-generation non-nucleoside inhibitor of HIV-1 reverse transcriptase (RT) that has recently been approved for use against HIV-1 infection. Compared with first-generation drugs such as nevirapine, efavirenz shows greater resilience to drug resistance mutations within HIV-1 RT. In order to understand the basis for this resilience at the molecular level and to help the design of further-improved anti-AIDS drugs, we have determined crystal structures of efavirenz ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0969-2126(00)00513-x
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- Journal:
- Structure (London, England : 1993)
- Volume:
- 8
- Issue:
- 10
- Pages:
- 1089-1094
- Publication date:
- 2000-10-05
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- URN:
-
uuid:0cf86b7b-4cd3-4b92-aa59-f74b1d163535
- Source identifiers:
-
13846
- Local pid:
- pubs:13846
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
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