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Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.

Abstract:

BACKGROUND: Efavirenz is a second-generation non-nucleoside inhibitor of HIV-1 reverse transcriptase (RT) that has recently been approved for use against HIV-1 infection. Compared with first-generation drugs such as nevirapine, efavirenz shows greater resilience to drug resistance mutations within HIV-1 RT. In order to understand the basis for this resilience at the molecular level and to help the design of further-improved anti-AIDS drugs, we have determined crystal structures of efavirenz ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Structure (London, England : 1993)
Volume:
8
Issue:
10
Pages:
1089-1094
Publication date:
2000-10-05
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:0cf86b7b-4cd3-4b92-aa59-f74b1d163535
Source identifiers:
13846
Local pid:
pubs:13846

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