Journal article
Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
- Abstract:
-
BACKGROUND: Efavirenz is a second-generation non-nucleoside inhibitor of HIV-1 reverse transcriptase (RT) that has recently been approved for use against HIV-1 infection. Compared with first-generation drugs such as nevirapine, efavirenz shows greater resilience to drug resistance mutations within HIV-1 RT. In order to understand the basis for this resilience at the molecular level and to help the design of further-improved anti-AIDS drugs, we have determined crystal structures of efavirenz ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s0969-2126(00)00513-x
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Bibliographic Details
- Journal:
- Structure (London, England : 1993)
- Volume:
- 8
- Issue:
- 10
- Pages:
- 1089-1094
- Publication date:
- 2000-10-01
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- Source identifiers:
-
13846
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:13846
- UUID:
-
uuid:0cf86b7b-4cd3-4b92-aa59-f74b1d163535
- Local pid:
- pubs:13846
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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