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Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells.

Abstract:

The mechanism of oxygen sensing in arterial chemoreceptors is unknown but has often been linked to mitochondrial function. A common criticism of this hypothesis is that mitochondrial function is insensitive to physiological levels of hypoxia. Here we investigate the effects of hypoxia (down to 0.5% O2) on mitochondrial function in neonatal rat type-1 cells. The oxygen sensitivity of mitochondrial [NADH] was assessed by monitoring autofluorescence and increased in hypoxia with a P50 of 15 mm H...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
The Journal of physiology
Volume:
591
Issue:
Pt 14
Pages:
3549-3563
Publication date:
2013-07-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:0cf7bf80-61e2-4253-a633-af068823ba92
Source identifiers:
401957
Local pid:
pubs:401957

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