- Abstract:
-
The mechanism of oxygen sensing in arterial chemoreceptors is unknown but has often been linked to mitochondrial function. A common criticism of this hypothesis is that mitochondrial function is insensitive to physiological levels of hypoxia. Here we investigate the effects of hypoxia (down to 0.5% O2) on mitochondrial function in neonatal rat type-1 cells. The oxygen sensitivity of mitochondrial [NADH] was assessed by monitoring autofluorescence and increased in hypoxia with a P50 of 15 mm H...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1113/jphysiol.2013.257741
-
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- Journal:
- The Journal of physiology
- Volume:
- 591
- Issue:
- Pt 14
- Pages:
- 3549-3563
- Publication date:
- 2013-07-05
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- URN:
-
uuid:0cf7bf80-61e2-4253-a633-af068823ba92
- Source identifiers:
-
401957
- Local pid:
- pubs:401957
- Copyright date:
- 2013
Journal article
Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells.
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