- Abstract:
-
Myelodysplastic syndromes (MDSs) are a group of hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral blood cytopenias. Lenalidomide has dramatic therapeutic effects in patients with low-risk MDS and a chromosome 5q31 deletion, resulting in complete cytogenetic remission in >60% of patients. The molecular basis of this remarkable drug response is unknown. To gain insight into the molecular targets of lenalidomide we investigated its in vitro effects on...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0610477104
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 104
- Issue:
- 27
- Pages:
- 11406-11411
- Publication date:
- 2007-07-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:0cf7a7e5-2ff0-4626-a234-f1877818f458
- Source identifiers:
-
246233
- Local pid:
- pubs:246233
- Copyright date:
- 2007
Journal article
Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.
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